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Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
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在基于细胞的检测中建立体外功效与经批准的GLP-1受体激活剂的临床有效度之间的关系

Alessandro Boianelli1, Pär Nordell1, Joseph Earl2

  • 1DMPK, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, 431 83 Mölndal, Sweden.

Pharmaceutics
|October 26, 2024
PubMed
概括

类似葡萄糖-1受体激动剂 (GLP-1RAs) 显示在体内有效性得到改善,当体内有效性在没有血清白蛋白的情况下测量时. 这一发现有助于预测人体剂量和设计新GLP-1RAs试验.

关键词:
作为GLP-1的激动剂.在 PK/PD 建模中,使用 PK/PD 模型.在体外和体内相对相关性基于模型的药物开发 (MIDD)

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