杀菌对in situ凝形成聚合物稳定性的作用
Elena O Bakhrushina1, Alina M Afonina1, Iosif B Mikhel1
1A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia.
Polymers
|October 26, 2024
概括
消毒刺激敏感药物输送系统是具有挑战性的,因为目前的方法可以降低药物特性. 本综述提供了有效的风险管理策略,用于开发无菌的现场药物输送系统.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
背景情况:
- 敏感于刺激的药物输送系统,特别是使用智能聚合物的现场存储系统,正在获得亲肠道输送的吸引力.
- 无菌性是所有门和眼部剂型的关键要求,包括这些先进的系统.
- 现有的灭菌方法带来了改变聚合物构成和活性药物成分 (API) 的重大风险,损害了药物的疗效和系统性能.
研究的目的:
- 解决关于风险评估和降低风险的不足文献,以消毒敏感的刺激系统.
- 为管理绝育相关风险提供基于证据的建议和方法.
- 引导开发稳定和无菌的现场药物输送配方.
主要方法:
- 对已发表的关于杀菌技术及其对智能聚合物和API的影响的实验数据的审查和综合.
- 分析与各种灭菌方法 (如热,辐射,过) 相关的风险因素.
- 在杀菌过程中制定稳定刺激敏感成分的策略.
主要成果:
- 目前的灭菌方法可能会对智能聚合物和API的物理化学和药理性质产生负面影响.
- 关于在现场药物输送系统灭菌的具体挑战和解决方案,存在重大知识差距.
- 有效的风险管理需要仔细选择和优化适合特定系统组件的灭菌技术.
结论:
- 开发无菌的现场药物输送系统需要采取积极的方法来管理灭菌风险.
- 提供了建议,以稳定刺激敏感系统,并保持其完整性和功能消毒后.
- 需要进一步的研究和标准化的协议,以确保这些先进的药物输送技术的安全和有效的临床转化.
相关概念视频
01:26Polymer Classification: Stereospecificity
2.4K
Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
2.4K
01:30Methods of Sterilization II: Chemical Methods
6.2K
In healthcare, the chemical method of sterilization uses chemical sterilants to treat surgical instruments and medical supplies to help prevent the transmission of infectious pathogens to patients. Due to heat sensitivity, most medical supplies and equipment should not be exposed to high temperatures. These parts include rubber, plastic, glass, and other similar elements.
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
6.2K
01:03Step-Growth Polymerization: Overview
3.4K
Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
Many natural and synthetic polymers are produced by...
3.4K
01:08Molecular Weight of Step-Growth Polymers
2.2K
Step growth polymerization involves bi or multifunctional monomers. Bifunctional monomers react to form linear step growth polymers, whereas multifunctional monomers react to form non-linear or branched polymers.
As the step-growth polymerization involves step-wise condensation of monomers, the molecular weight also builds up eventually. Consequently, high molecular weight polymers are obtained at the late stages of the polymerization, where 99% of monomers have been consumed.
The extent of the...
As the step-growth polymerization involves step-wise condensation of monomers, the molecular weight also builds up eventually. Consequently, high molecular weight polymers are obtained at the late stages of the polymerization, where 99% of monomers have been consumed.
The extent of the...
2.2K