泰国草药的抗高血糖作用 泰国草药的抗高血糖作用
Athit Bunyakitcharoen1, Weerakit Taychaworaditsakul2, Seewaboon Sireeratawong3,4
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Plants (Basel, Switzerland)
|October 26, 2024
概括
这项研究探讨了泰国药用植物的抗氧化和抗高血糖特性,以对抗糖尿病. 树 officinale 显示出强大的抗氧化和降血糖效应,从而为进一步的动物研究带来了有前途的R1疗法.
科学领域:
- 药理学和民族植物学
- 自然产品化学 自然产品化学
- 代谢性疾病研究研究
背景情况:
- 糖尿病是一种全球性健康问题,需要新的治疗策略.
- 传统的药用植物提供了丰富的生物活性化合物的来源,用于管理高血糖症.
- 泰国药用植物以其潜在的抗糖尿病特性而闻名.
研究的目的:
- 评估选定泰国药用植物的抗氧化和抗高血糖活性.
- 确定具有开发糖尿病自然疗法显著潜力的植物提取物.
- 评估植物化学物质含量,抗氧化能力和特定的抗糖尿病机制.
主要方法:
- 七种泰国药用植物 (Coccinia grandis,Gymnema inodorum,Gynostemma pentaphyllum,Hibiscus sabdariffa,Momordica charantia,Morus alba,Zingiber officinale) 的乙醇原料提取物使用索克斯莱特提取物进行制备.
- 植物化学查,确定总和黄含量.
- 在体外测定抗氧化活性 (DPPH,ABTS),α-葡萄糖酶抑制,以及胰岛素抵抗性HepG2细胞中的葡萄糖消耗.
主要成果:
- 紫官提取物表现出最高的总和黄含量,以及强大的DPPH和ABTS激素清除活性 (IC50值:分别为19.16和8.53μg/mL).
- 葡萄树Morus alba和Gynostemma pentaphyllum显示出显著的α-葡萄糖酶抑制活性 (IC50值:分别为134.40和329.97μg/mL).
- 树 officinale 和 Hibiscus sabdariffa 显示出最高的葡萄糖消耗活性 (分别为 145.16% 和 107.03% 在 50 微克/毫升). 开发的R1疗法显示出显著的抗高血糖潜力 (IC50:122.10μg/mL).
结论:
- 选择的泰国药用植物,特别是Zingiber officinale,具有显著的抗氧化和抗高血糖特性.
- 从这些植物提取物中提取的R1疗法显示为降低血糖水平的有效药物.
- 需要进一步的体内研究来验证R1药物在糖尿病管理中的治疗潜力.
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