连续脏替代疗法期间在过器上Linezolid吸附:一个体外研究.
Krzysztof Nosek1, Milena Samiec1,2, Hubert Ziółkowski3
1Department of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury, Al. Warszawska 30, 10-082 Olsztyn, Poland.
Pharmaceuticals (Basel, Switzerland)
|October 26, 2024
概括
在连续脏置换疗法 (CRRT) 期间,聚乙烯胺胺处理的多烯二 (PAN PEI) 过器显著吸附线化物,影响药物度. 需要进一步的体内研究来证实这些发现在患者身上.
科学领域:
- 科和重症监护中心
- 药理动力学和药理动力学
- 生物材料和医疗设备工程 生物材料和医疗设备工程
背景情况:
- 持续性置换疗法 (CRRT) 在败血症中用于清除毒素和细胞因子,但可能会改变抗菌药物清除率.
- 达到目标的药理动力学/药理动力学 (PK/PD) 指数对于在败血症期间有效的抗生素治疗至关重要.
- 透析过器对抗生素的吸附可能会影响其有效性.
研究的目的:
- 为了研究线化物的体外吸附到三个不同的CRRT过器类型.
- 通过聚硫 (PS),聚乙烯胺胺处理的多烯 (PAN PEI) 和未经PEI处理的多烯 (PAN) 过器量化linezolid吸附.
主要方法:
- 在实验室中使用PS,PAN PEI和PAN过器进行了持续静脉静脉血过 (CVVH).
- 莱涅佐利德 (600毫克) 溶于牛血或0.9%的NaCl溶液 (700毫升),总体体积为1000毫升.
- 药物度在时间点上测量,并使用单向ANOVA与Tukey后期测试 (p <0.05) 分析吸附差异.
主要成果:
- 在牛血和NaCl溶液中使用PAN PEI过器观察到显著的linezolid吸附.
- 在120分钟内,NaCl中的线化物度下降了52% (从594.74到310.66微克/毫升),血液中的度下降了73% (从495.18到359.84微克/毫升).
- 使用PAN或PS过器检测到没有显著的线化物吸附.
结论:
- CRRT过器的类型显著影响线化物吸附,PAN PEI过器显示出大量的药物去除.
- 这些发现凸显了过器选择在接受CRRT的患者中对linezolid疗效的潜在影响.
- 需要进一步的体内研究来验证这些体外结果并指导临床实践.
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