静脉血栓栓塞的概述和基于纳米载体介导药物输送系统的新兴治疗技术
Masoud Salavati1, Arman Arabshomali2, Sasan Nouranian1
1Department of Chemical Engineering, University of Mississippi, Oxford, MS 38677, USA.
Molecules (Basel, Switzerland)
|October 26, 2024
概括
静脉血栓塞栓症 (VTE) 存在重大风险,包括复发和并发症. 本综述检查了正在进行的抗凝试验和新型纳米载体疗法,以改善静脉瘤治疗和预防.
科学领域:
- 医学研究 医学研究
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
背景情况:
- 静脉血栓栓塞 (VTE) 是导致疾病和死亡的主要原因,复发率很高.
- 目前的治疗方法,如抗凝药,有局限性,严重的病例可能需要进行血栓消毒疗法.
- 对于更安全,更有效的VTE疗法存在重大未满足的需求.
研究的目的:
- 审查正在进行的针对VTE抗凝剂干预的临床试验.
- 评估这些干预措施在预防深静脉血栓塞 (DVT) 进展为肺栓塞 (PE) 和血栓复发方面的疗效.
- 总结抗血小板治疗的证据和针对VTE的向纳米载体药物输送的进展.
主要方法:
- 在clinicaltrials.gov.gov上列出的VTE抗凝剂试验的系统审查.
- 对新型抗凝血药物作用机制的分析.
- 支持抗血小板药物和基于纳米载体的治疗方法对VTE的证据的评估.
主要成果:
- 目前正在进行的试验正在探索VTE的新型抗凝剂机制.
- 目前正在收集关于抗血小板治疗在VTE管理中的有效性的证据.
- 针对血栓的纳米载体显示出希望,但在临床应用中面临挑战.
结论:
- 新的抗凝药物和向的纳米载体系统正在开发中,以解决VTE.
- 需要进一步的研究来优化这些疗法,以防止VTE的进展和复发.
- 提高VTE治疗的安全性和有效性仍然是一个关键目标.
相关概念视频
01:29Venous Thrombosis III: Interprofessional Care
2
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
2
01:30Venous Thrombosis IV: Nursing Management
2
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
2
01:30Venous Thrombosis I: Introduction
2
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
2
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
625
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
625
01:27Pulmonary Embolism III: Nursing Management
1
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
1