交叉连接的可生物降解的混合基基基基基基基为药物控制释放
Zhenzhen Zhao1, Zihao Qin2, Tianqing Zhao3
1School of Advanced Agricultural Science, Weifang University, Weifang 261061, China.
Molecules (Basel, Switzerland)
|October 26, 2024
概括
由聚乙烯甘醇 (PEG) 和凝制成的新混合水凝被开发用于控制释放Cefazedone (CFD) 抗生素. 这些生物相容的水凝为持续的药物输送提供了可调节的特性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 控制的药物输送系统对于治疗疗效和患者的遵守至关重要.
- 由于其可调节的特性,水凝为药物封装和释放提供了多功能平台.
- 聚乙烯甘醇 (PEG) 和凝是生物相容的聚合物,具有创造先进水凝配方的潜力.
研究的目的:
- 合成和描述由聚乙烯糖醇 (PEG) 和凝组成的新型混合液体.
- 调查固体含量和交联度对水凝特性和Cefazedone (CFD) 释放的影响.
- 评估生物医学应用开发的水凝的细胞相容性.
主要方法:
- 合成四臂PEG-succinimidyl酸盐 (4臂PEG-SG) 并随后形成凝-PEG复合水凝 (SnNm).
- 描述水凝特性,包括热稳定性,机械强度,膨胀率,降解和药物释放动力学.
- 使用MTT试验进行细胞毒性评估,以确定细胞活力.
主要成果:
- 越来越多的交联度和固体含量提高了热稳定性,膨胀率和机械性能.
- 调节了水凝的特性,以实现持续的降解和药物释放配置文件.
- 在60小时后,S1N1-III水凝显示了90%的质量损失,并在72小时内持续释放CFD.
- 细胞毒性测定表明细胞兼容性很好,细胞活力率超过95%.
结论:
- 开发的凝-PEG混合水凝为控制的抗生素输送提供了一个可调节的平台.
- 这项研究展示了一种有前途的方法,用于创建具有针对生物医学应用的特性的先进水凝.
- 这些材料表现出极好的细胞兼容性,支持它们在药物输送系统中的潜在用途.
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