学生中的甲素耐药黄金葡萄球菌:鼻腔携带率,促进因素和抗菌素敏感性
Ahsen Taqveem1,2, Muhammad Hidayat Rasool1, Bilal Aslam1
1Institute of Microbiology, Government College University Faisalabad, Faisalabad 38000, Pakistan.
Medicina (Kaunas, Lithuania)
|October 26, 2024
概括
一项研究发现,14%的学生携带金黄色葡萄球菌,其中5.5%携带耐甲林金黄色葡萄球菌 (MR-SA). 观察到高抗微生物耐药性,强调了教育环境中需要对抗生素进行管理,以制细菌传播.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 金黄色葡萄球菌 (Staphylococcus aureus) 是一种常见的人类细菌,可以引起感染.
- 甲素耐药金黄色细菌 (MR-SA) 由于过度使用抗生素,越来越令人担忧.
- 在医疗保健工作者和普通人群中观察到MR-SA鼻腔携带的增加.
研究的目的:
- 确定在教育机构的学生中S. aureus和MR-SA鼻传播的流行率.
- 为了表征S. aureus分离体的表型特征.
- 评估S. aureus和MR-SA.的抗菌素耐药性概况.
主要方法:
- 从各个教育机构的学生那里收集了1200个鼻子抽样.
- 使用基于培养的方法 (血液和曼尼托盐) 和生物化学测试进行鉴定.
- 进行了抗微生物敏感性测试 (Kirby-Bauer盘扩散) 和最小抑制度 (MIC) 确定.
- 利用PCR放大核和mecA基因进行确认.
主要成果:
- 14%的学生是S. aureus的鼻腔携带者 (8.5%的MSSA,5.5%的MR-SA).
- 在男性和城市学生中,分别发现金黄色细菌和MR-SA的更高患病率.
- 发现对红红素 (80.3%),诺基诺隆 (47.6%) 和克林达米辛 (42.2%) 的显著耐药性.
- 所有分离物仍然对万科米辛和线索立德敏感;95.5%的MR-SA分离物携带了mecA基因.
结论:
- 教育机构可以充当多药耐药 (MDR) 黄金杆菌传播的储存库.
- 滥用抗生素有助于细菌耐药性和感染的增加.
- 在学校实施抗生素管理计划和控制策略至关重要,以对抗S. aureus和MR-SA.
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