在接受整形外科手术的老年患者中,与年龄相关的对雷米马佐拉姆的反应:单中心前性观察性研究
Min Suk Chae1, Nuri Lee1, Hyun Jung Koh1
1Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Medicina (Kaunas, Lithuania)
|October 26, 2024
概括
雷米马佐拉姆是一种安全有效的麻醉剂,适用于接受骨科手术的老年患者,不存在与年龄相关的显著反应或不良事件的差异. 这种超短效的二胺可确保稳定的血液动力学和快速恢复.
科学领域:
- 麻醉学 麻醉学
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 雷米马佐拉姆是一种超短效的二甲,用于程序镇静和全身麻醉.
- 它提供了快速发病,不活跃的代谢物,快速恢复,以及有利的安全性,即使在高风险和老年患者.
- 它的血液动力学和呼吸系统稳定性与现有的麻醉剂相当.
研究的目的:
- 评估雷米马佐拉姆在接受全膝关节整形手术 (TKA) 的老年患者的安全性和疗效.
- 为了比较年轻 (65-74岁) 和老年 (75-85岁) 老年人群之间的麻醉反应和恢复特征.
- 评估需要弗卢马泽尼尔的需要,达到特定双光谱指数 (BIS) 水平的时间,以及呼吸暂停率.
主要方法:
- 一项前性观察性研究,涉及110名预定接受初级TKA的老年患者.
- 患者被分为两组:65至<75岁 (n=52) 和75至85岁 (n=47).
- 雷米马拉姆输液方案:6 mg/kg/h 3 分钟,然后1 mg/kg/h. 使用了标准化的手术和麻醉程序.
主要成果:
- 弗卢马泽尼尔的使用在各年龄组之间是相似的.
- 在达到BIS<60的时间或呼吸暂停的发生率方面没有观察到显著的差异.
- 恢复指标,包括BIS>80和完全意识的时间,在两组老年人中都是可比的.
结论:
- 雷米马佐拉姆在接受骨科手术的老年患者中耐受性良好,反应与年龄相关的变化最小.
- 麻醉剂提供有效的深度,没有显著的不良后果,支持其在这个人群中的使用.
- 类似的剂量策略似乎适用于年轻和年长的老年患者.
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