胰岛素抵抗和肌肉质量的年龄相关变化:肥胖老年人的临床影响
Ali A Rizvi1, Manfredi Rizzo2,3
1Department of Medicine, Division of Endocrinology, Orlando VA Medical Center and University of Central Florida College of Medicine, Orlando, FL 32827, USA.
Medicina (Kaunas, Lithuania)
|October 26, 2024
概括
肥胖症,肌肉损失和多余的体脂的结合,越来越多地影响着老年人. 这种情况会恶化胰岛素抵抗和炎症,导致严重的健康问题,如心脏病和糖尿病.
科学领域:
- 老年学是指老年学的学科.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 全球人口正在迅速老龄化,预期寿命也在增加.
- 超重和肥胖率在所有年龄组都在上升.
- 衰老与肌肉质量和功能下降 (肉类衰老) 有关.
研究的目的:
- 为了定义sarcopenic肥胖症及其对老年人的健康影响.
- 了解病理生理机制,将sarcopenic肥胖与不良结果联系起来.
- 为了探索对型肥胖症的潜在治疗策略.
主要方法:
- 关于衰老,肥胖和肉症的当前文献的综述.
- 分析病理生理学联系,包括胰岛素抵抗和炎症.
- 对分子和细胞失调的探索.
主要成果:
- 肥胖症加剧了胰岛素耐药性,并促进了炎症状态.
- 这种情况会增加患心血管疾病,2型糖尿病和认知能力下降的风险.
- 了解分子基础对于定义疾病结构至关重要.
结论:
- 肥胖症是一种新出现的疾病,对老年人群造成重大健康后果.
- 生活方式的修改,补充剂和抗氧化剂在管理方面表现有前途.
- 需要对药物治疗进行进一步的研究,以逆转或减缓其进展.
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