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耐火复发性紧突巨细胞瘤 (TGCT) 的治疗方法:最新情况

Vasiliki Dania¹, Nikolaos A Stavropoulos¹, Panayiotis Gavriil¹

¹First Department of Orthopedic Surgery, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University General Hospital, 12462 Athens, Greece.

Medicina (Kaunas, Lithuania)

|October 26, 2024

概括

长巨细胞瘤 (TGCT) 是一种良性瘤,复发率很高,特别是扩散型TGCT. 手术切除是标准的,但耐火病例需要探索替代的全身疗法.

科学领域:

在瘤学瘤学.
整形外科整形外科整形外科
病理学病理学病理学

背景情况:

长巨细胞瘤 (TGCT) 是一种罕见的,局部具有侵略性的良性瘤.
它来自突膜,肌罩和毛囊,具有局部 (L-TGCT) 和扩散 (D-TGCT) 亚型.
高复发率,特别是D-TGCT,挑战了外科切除作为唯一的治疗方法.

研究的目的:

审查目前关于耐火性和复发性TGCT治疗方法的文献.
突出了除了外科切除之外的替代疗法的需要.

主要方法:

对耐火性复发TGCT当前治疗选择的文献综述.
对手术和全身疗法现有数据的分析.

主要成果:

手术切除仍然是TGCT治疗的黄金标准.
增加的复发率和耐药性疾病,特别是在D-TGCT中,突显了需要额外的治疗替代方案.
系统疗法越来越多地用于复发的TGCT病例.

结论:

虽然TGCT是良性的,但它可能具有破坏性,侵略性,并影响生活质量.
最佳的手术方法取决于瘤的位置和程度.
系统疗法为治疗复发性和耐火性TGCT提供了一个有希望的途径.

关键词:

扩散类型的扩散类型巨细胞瘤巨细胞瘤局部化类型的局部化类型长突巨细胞瘤.

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