在患有炎症性肠病的患者中与代谢功能障碍相关的脂肪性肝病:试点研究
Ludovico Abenavoli1, Rocco Spagnuolo1, Giuseppe Guido Maria Scarlata1
1Department of Health Sciences, University "Magna Græcia", Viale Europa, 88100 Catanzaro, Italy.
Life (Basel, Switzerland)
|October 26, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响18%的炎症性肠病 (IBD) 患者,通常与更高的疾病活性和心脏代谢风险有关. 早期检测和多学科管理对于这一处于危险的群体至关重要.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 代谢疾病 代谢疾病
- 临床研究 临床研究
背景情况:
- 炎症性肠病 (IBD) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 相关,原因是肠道失调和炎症等共同的风险因素.
- 更新的MASLD命名法强调了肝脏肥胖症与心脏代谢疾病的联系.
- 在IBD患者中MASLD的患病率尚未确立.
研究的目的:
- 用超声波来确定意大利IBD患者中MASLD的患病率.
- 在这个队列中研究MASLD的临床特征.
- 确定IBD中MASLD的潜在预测因子.
主要方法:
- 一项对272名意大利IBD患者 (2021年1月至2023年12月) 的回顾性研究.
- 根据既定指导方针,根据肝硬化和心脏代谢风险因素进行MASLD诊断.
- 收集和分析人口,临床和实验室数据;统计显著性设置为p < 0.05.
主要成果:
- 在18%的IBD患者中发现了MASLD,而非酒精性脂肪性肝病 (NAFLD) 的患者为6%.
- IBD-MASLD患者年龄较大,BMI,腰围,甘油三和2型糖尿病和高血压的患病率较高.
- IBD-MASLD与更高的疾病活性和更多的手术干预有关;高的甘油三预测了MASLD.
结论:
- 在IBD患者中,MASLD比以前认为的更为普遍,强调需要进行肝硬化查.
- 在IBD中,MASLD和心脏代谢因素之间的联系需要一个多学科的管理策略.
- 需要在更大的队列中进行进一步的研究,以验证发现并阐明潜在的机制.
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