杜普伊特伦病的治疗方法:原酶治疗-长期随访研究
Nikolaus Wachtel1, Francesca Romana Dingler1, Tim Nürnberger1
1Department of Hand, Plastic and Aesthetic Surgery, LMU Klinikum, Ziemssenstraße 5, 80336 Munich, Germany.
Life (Basel, Switzerland)
|October 26, 2024
概括
原酶注射为杜普伊特伦收缩症提供了显著的长期改善,特别是在手指关节. 然而,糖尿病和尼古丁使用的患者可能会经历更糟糕的结果.
科学领域:
- 整形外科 整形外科 整形外科
- 手术手术手术手术手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 杜普伊特伦病是一种连接组织疾病,影响手掌,主要发生在老年白人男性身上.
- 传统的手术断层切除术和较新的微侵袭性原酶注射是治疗选择.
- 对原酶注射的长期疗效数据仍然有限.
研究的目的:
- 为了评估原酶注射对杜普伊特伦合症的长期有效性.
- 评估复发率并确定不良结果的风险因素.
主要方法:
- 一个单一的回顾性研究,35名患者接受了原酶 (Xiapex) 注射治疗.
- 在局部麻醉下进行内射注射,然后在局部麻醉下被动伸展指.
- 临床随访平均为5.7年,记录了使用Tubiana分类和关节特定伸展能力的合症.
主要成果:
- 在MCP (42°至17°) 和PIP (56°至33°) 关节 (p ≤0.001) 观察到手指收缩的长期显著改善.
- 主要复发率为MCP的11%和PIP关节的19%.
- 糖尿病和尼古丁滥用被确定为较差的长期结果的显著风险因素.
结论:
- 原酶疗法为杜普伊特伦合症提供了显著而持久的改善.
- 糖尿病和尼古丁滥用患者面临低于最佳的长期结果的风险增加.
- 这种最少的侵入性技术是有效的和低风险的治疗残疾杜普伊特伦合症.
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