怀孕期间感染对跨胎盘抗体转移的影响
Celeste Coler1, Elana King-Nakaoka1, Emma Every1
1School of Medicine, University of Washington, Seattle, WA 98195, USA.
Vaccines
|October 26, 2024
概括
母亲接种疫苗可以保护新生儿,但感染可以减少抗体穿过胎盘的转移. 了解这些机制对于疫情准备和婴儿健康至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 孕产妇与胎儿的医学
- 传染病 传染病 传染病
背景情况:
- 通过胎盘转移的母体抗体保护新生儿,直到他们的免疫系统发育.
- 在怀孕期间对母亲进行疫苗接种对于保护母亲和胎儿免受感染至关重要.
- 众所周知,几种病原体会对母体抗体向胎儿的转移产生负面影响.
研究的目的:
- 审查孕产妇感染损害跨胎盘抗体转移的机制.
- 突出了解这些机制对于流行病准备的重要性.
- 强调最大限度地提高母体疫苗接种对婴儿健康的益处.
主要方法:
- 本综述综合了关于孕产妇感染及其对胎盘抗体转移的影响的现有文献.
- 讨论的机制包括抗体糖化酶的变化,孕产妇的高糖球蛋白血症和胎盘损伤.
- 该审查审查了诸如艾滋病毒,疟疾,SARS-CoV-2和细胞巨乳病毒等病原体.
主要成果:
- 孕产妇感染可以降低从母亲到胎儿转移抗体的效率.
- 具体的机制包括抗体结构的变化 (糖化),高水平的母体抗体,以及对胎盘的损伤.
- 诸如艾滋病毒,疟疾,SARS-CoV-2和CMV等病原体破坏了这一重要的转移过程.
结论:
- 传染病通过各种机制显著损害了母胎抗体转移.
- 了解这些干扰对于制定战略来加强在流行病和流行病期间对婴儿的保护至关重要.
- 优化母体疫苗接种策略对于在传染病威胁日益增加的时代保护儿童健康至关重要.
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