在2型糖尿病患者中,营养不良和不良结局之间的关联
Momoko Fujiwara1, Hiroshi Kimura1,2, Kenichi Tanaka1,2
1Department of Nephrology and Hypertension, Fukushima Medical University, Fukushima, Japan.
营养状况不佳,以低老年营养风险指数 (GNRI) 为标志,与2型糖尿病患者的更糟糕的脏结果和更高的死亡率有关. 这突出了GNRI的重点.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
背景情况:
- 营养状况对于慢性病 (CKD) 患者,特别是糖尿病患者来说至关重要.
- 在2型糖尿病 (T2D) 管理中,评估营养状况和识别营养不良至关重要.
- 关于T2D中营养指数和功能之间的关系的证据有限.
研究的目的:
- 研究老年营养风险指数 (GNRI) 与T2D患者的预后之间的关联.
- 确定GNRI是否可以作为T2D中不良结果的预后工具.
主要方法:
- 分析了福岛队列研究中的946名T2D患者队列.
- 主要终点是事件 (50%的eGFR下降或末期病).
- 考克斯回归分析评估了GNRI与脏事件,全因死亡和心血管事件之间的关联.
主要成果:
- 与最高GNRI三位数相比,最低GNRI三位数的患者患事件 (HR 5.15) 和全因死亡 (HR 2.30) 的风险明显更高.
- 在GNRI水平和心血管事件之间没有发现显著的关联.
- 患者的中位数年龄为66岁,中位数eGFR为67.9mL/min/1.73m2,中位数GNRI为100.0.
结论:
- 根据GNRI的评估,营养状况不佳与T2D患者的不良结果有关.
- GNRI证明了作为T2D患者的预后指标的潜在实用性.
- 营养评估对于预测T2D的预后非常有价值.
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