皮下斑块和炎症反映了渐进性多发性硬化症中的皮层和脑膜病理
Betül Okutan1, Jette L Frederiksen1,2, Gunnar Houen1,3
1Department of Neurology, Danish Multiple Sclerosis Center, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark.
Brain pathology (Zurich, Switzerland)
|October 26, 2024
概括
在多发性硬化症 (MS) 中,皮质下/皮下白质病变可能反映皮质和脑膜炎症. 这些病变可以作为MRI替代品,用于更深层次的病理,有助于监测和认知评估在渐进的MS.
科学领域:
- 神经免疫学 神经免疫学
- 神经病理学神经病理学
- 放射学 放射学是一门学科.
背景情况:
- 在多发性硬化症 (MS) 中,下/近皮层白质病变和皮层/脑膜病理之间的关系尚不清楚.
- 了解这种联系对于改善MRI监测至关重要,因为皮质下/皮质前皮层病变是可见的,与皮质病变和脑膜炎症不同.
研究的目的:
- 调查MS中白质病变和炎症是否与皮质和脑膜病理相关.
- 探索 sub/juxtacortical 病变作为MRI 替代物用于监测疾病活动和进展的潜力.
主要方法:
- 大面积显微镜被用来量化斑块负载和周血管单核细胞入子/近皮层白质,皮质和脑膜中的入量.
- 进行了组织学染色 (H&E,髓,小质/巨细胞,B/T细胞) 和IgG沉积分析.
- 分析了12名初级进展性多发性硬化症 (PPMS),15名二次进展性多发性硬化症 (SPMS) 患者和22名对照组的数据,将发现与临床参数相关联.
主要成果:
- 皮下/皮下板块活动反映了大脑皮层内的活动.
- 与皮质相比,炎症透物和斑块活性在皮质下/皮质前白质中更为明显,尽管皮质的总斑块负载更高.
- 透物显示出皮层间的相关性,而皮层下/皮层附近的斑块活动反映出皮层和脑膜透物. 入物大小与进展后发病后生存率降低相关.
结论:
- 皮质下/皮质前白质病变和相关炎症可以作为可靠的MRI替代品,用于皮质和脑膜病理在渐进的MS.
- 这些发现表明,要强调下/上皮层MRI病变,以监测疾病活动,并可能指导MS患者的认知测试.
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