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空气污染对皮肤微生物群的影响:与皮肤屏障功能障碍的联系

Suphagan Boonpethkaew^1,2, Sasin Charoensuksira¹, Jitlada Meephansan^3,4

¹Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Klong Luang, Pathum Thani, 12120, Thailand.

Archives of dermatological research

|October 26, 2024

概括

空气污染对皮肤微生物组产生负面影响,减少多样性并破坏有益细菌. 这导致皮肤水分减少和pH值增加,可能导致皮肤屏障功能障碍.

科学领域:

皮肤病学皮肤病学
微生物学微生物学
环境科学环境科学

背景情况:

皮肤微生物组的平衡对于皮肤屏障功能至关重要.
像空气污染这样的外部因素会破坏这种平衡.
了解空气污染对皮肤微生物群的影响至关重要.

研究的目的:

研究环境空气污染对皮肤微生物群的影响及其与皮肤屏障参数的相关性.
为了比较高污染空气 (HPA) 和低污染空气 (LPA) 环境中的女性之间的皮肤微生物组概况和屏障功能.

主要方法:

从曼谷 (HPA) 和桑克拉 (LPA) 招募了健康的女性.
测量了额头皮肤上的皮肤屏障生理参数.
采集和分析额头皮肤微生物组资料,使用片测序.

主要成果:

暴露于HPA的皮肤中的真菌属和细菌物种水平下降了微生物群的多样性.
在暴露于LPA的皮肤中,Streptococcus parasanguinis的丰富程度较高,与皮肤pH值较低和角层 (SC) 水分较高相关.
增加了马拉塞西亚 spp. 和Aureobasidum spp. 这种植物. 在暴露于HPA的皮肤中,与较高的皮肤间流失水和较低的SC水分相关联.

结论:

空气污染减少了皮肤微生物群的多样性.
它破坏了有益的微生物群-屏障生理学相关性.
它促进了致病性微生物群的过度生长,导致皮肤屏障功能障碍.

关键词:

空气污染大气污染安普利康序列测序的使用.炎症性皮肤病是一种炎症性皮肤病.微生物组是一个微生物组.皮肤障碍物皮肤障碍物皮肤质量皮肤质量

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