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基于莱西丁的混合聚合物微粒用于改善黄素对黄金葡萄球菌的活性

Yunjing Jia¹, Yuli Li¹, Mingzhu Wang¹

¹School of Biological Science and Technology, University of Jinan, Jinan, Shandong Province, China.

Journal of biomaterials science. Polymer edition

|October 26, 2024

概括

增强大豆莱西丁的黄菌素 (MPPC) 通过促进细胞吸收来改善抗黄菌的活性. 这种配方有效地向细菌生物膜和细胞膜,提供了增强药物递送的潜力.

科学领域:

纳米技术用于药物输送.
抗微生物研究的研究.
材料科学是一种材料科学.

背景情况:

黄金葡萄球菌表现出高脂酶表达,表明对基于莱西丁的疗法易感.
黄素 (Cur) 具有抗微生物特性,但其水溶性和生物可用性较差.
豆素可以增强细胞吸收,这是有效的抗微生物药物递送的关键因素.

研究的目的:

设计和评估黄素加载的基于大豆莱西丁的mPEG-PVL共聚物微粒 (MPPC) 以增强抗黄球菌活性.
调查大豆莱西丁在提高黄素配方对S. aureus的疗效方面的作用.
评估MPPC对细菌生物膜,细胞膜完整性,酶生产和反应性氧物种 (ROS) 生成的影响.

主要方法:

合成含有黄素 (Cur) 的mPEG-PVL共聚合物微粒.
将大豆莱西丁纳入小粒,形成MPPC.
对MPPC和对照小粒 (没有大豆莱素的MPC) 进行对黄素释放,S. aureus抑制,生物膜破坏,细胞膜损伤,酶抑制和ROS诱导的比较分析.

主要成果:

MPPC显示水溶性增强和库尔库持续释放.
与MPC相比,MPPC表现出明显更高的抗S. aureus活性,这归因于大豆莱西丁的细胞吸收促进.
与Cur和MPC相比,MPPC表现出优异的生物膜抑制,显著的细胞膜损伤,强烈的蛋白酶/脂酶抑制,以及诱导的ROS表达.

结论:

将大豆莱西丁添加到含有黄素的粒中,大大提高了对S. aureus的抗菌功效.
基于莱西丁的菌体提供了一种有前途的策略,用于输送抗菌剂,通过改善细胞吸收和多面细菌向来增强其治疗作用.
MPPC 提出了一个可行的纳米载体系统,用于开发更有效的治疗方法来对抗金黄色细菌感染,包括那些涉及生物膜的治疗方法.

关键词:

库尔库明是一种黄素.抗菌的改善抗菌的改善莱西丁是一种莱西丁.mPEG-PVL 的时间.

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