肝功能的变化,血糖的波动,胰岛素分泌和性别差异在治疗后患有甲状腺功能增高的患者与甲醇化片结合甲基马片治疗后
Jianying Hu1, Jiajia Dong2, Weihong Huang1
1Department of Thyroid Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China.
Pakistan journal of pharmaceutical sciences
|October 26, 2024
概括
结合甲基马和普拉诺可显著改善甲状腺功能过高患者的治疗结果,增强肝功能和胰岛素耐药性. 这种组合疗法还可以降低血糖的变化,特别是在男性患者中.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲状腺功能障碍会导致显著的代谢障碍,包括肝功能改变,葡萄糖失调和胰岛素分泌受损.
- 目前的治疗主要集中在正常化甲状腺激素水平,但对相关代谢并发症的影响需要进一步调查.
研究的目的:
- 为了评估结合甲基马和普拉诺洛尔治疗与单独甲基马治疗甲状腺功能障碍症的疗效.
- 评估这种组合对肝功能,血糖控制和胰岛素分泌的影响.
- 检查治疗反应和代谢参数的基于性别的差异.
主要方法:
- 对110名甲状腺功能高的患者进行了回顾性分析,分为两组:单独使用甲基马 (n=55) 和甲基马与普拉诺洛尔 (n=55).
- 治疗前和治疗后的肝功能测试,动态血糖参数 (包括FBG,食后葡萄糖,LAGE,MAGE,MODD,SDBG) 和胰岛素分泌标记 (HOMA-IR,HOMA-β) 的比较.
- 在治疗前分析代谢参数的性别差异.
主要成果:
- 组合组与甲基马组 (83.64%) 相比,组合组的整体疗效 (96.35%) 显著提高 (83.64%).
- 在治疗后,组合组显示肝酶 (TBiL,AST,ALT),甲状腺激素 (FT3,FT4),血糖控制 (FBG,食后葡萄糖峰值) 和胰岛素耐药性标志物 (HOMA-IR,HOMA-β) 的改善,TSH水平较高.
- 女性患者的葡萄糖变化 (LAGE,MAGE,MODD,SDBG) 比男性患者低.
结论:
- 与甲基马和普拉诺洛尔的联合治疗比单独使用甲基马治疗甲状腺功能障碍更有效.
- 这种综合方法可以改善甲状腺和肝功能,增强胰岛素敏感性,减少血糖波动.
- 性别影响甲状腺功能过高患者的葡萄糖变化,女性显示的波动较小.
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