对acalabrutinib与ibrutinib在复发/耐药地幔细胞淋巴瘤中的匹配调整的间接比较
Ling Cai1, Jack Roos1, Paulo A P Miranda2
1AstraZeneca, South San Francisco, CA, USA.
Journal of medical economics
|October 26, 2024
概括
这项研究比较了acalabrutinib和ibrutinib用于复发/耐药的上衣细胞淋巴瘤. 虽然无进展生存率和总生存率相似,但acalabrutinib显示出更好的安全性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 复发性/耐药性地幔细胞淋巴瘤 (R/R MCL) 的治疗选择有限.
- 像acalabrutinib和ibrutinib这样的布鲁顿氨酸激酶抑制剂 (BTKis) 已被批准用于R/R MCL.
- 缺少对比试验,需要进行间接比较.
研究的目的:
- 为了比较acalabrutinib与ibrutinib在R/RMCL中的疗效和安全性,使用匹配调整间接比较 (MAIC).
- 使用比以前发布的MAIC更成熟的数据集进行可靠的比较.
主要方法:
- 使用122名接受acalabrutinib治疗的患者的个人患者数据进行了MAIC.
- 使用了三项ibrutinib试验的综合数据,根据关键基线特征进行匹配 (ECOG PS,MCL-SIPI,LDH,先前线,瘤负担,布拉斯组织学).
- 评估了无进展生存 (PFS),总生存 (OS) 和不良事件.
主要成果:
- 在PFS (HR=0.92;95%CI=0.74-1.15) 或OS (HR=0.87;95%CI=0.64-1.17) 中,在acalabrutinib和ibrutinib之间没有观察到统计学上显著的差异.
- 与ibrutinib相比,acalabrutinib显示了与ibrutinib相比,具有统计学意义的3级以上心房动和血小板狭窄率较低.
- 阿卡拉布鲁替尼的PFS中位数为17.8个月,而易布鲁替尼的PFS为12.8个月.
- 阿卡拉布鲁丁尼的中位寿命为36.5个月,而易布鲁丁尼的中位寿命为27.9个月.
结论:
- 阿卡拉布鲁丁尼和易布鲁丁尼在R/RMCL的PFS和OS方面表现出可比的疗效.
- 阿卡拉布鲁丁尼布提供了改进的安全性概况,具有显著较低的特定不良事件率.
- 这个MAIC为R/R MCL的治疗决策提供了宝贵的见解,当没有头对头数据可用时.
关键词:
在这里,我们可以看到C C C C CC00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C00 C1 C00 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C2 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 C1 没有一个人没有一个人C1 一个人的心态C1010 一个人的心态我已经开始了,我已经开始了.第111章 这是什么?一千一百一十,就是这样.地膜细胞淋巴瘤这是一个calabrutinib.伊布鲁丁尼布可以.匹配对分析的分析.非霍奇金淋巴瘤的非霍奇金淋巴瘤.更多相关视频
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