通过化学测量方法同时估计散装药物中的普拉苏格勒和阿司匹林
Urvish Desai1, Jenee Christian1, B N Suhagia1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, India.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
|October 26, 2024
概括
一种使用化学测量的新的UV-Vis光谱法,可以同时准确量化普拉苏格勒 (PRA) 和阿司匹林 (ASP). 这种绿色化学方法为制药分析提供了一种可持续,高效和成本效益的替代方案.
科学领域:
- 分析化学 分析化学
- 药品分析 药品分析
- 绿色化学 绿色化学
背景情况:
- 药品活性成分 (API) 的同时量化对于质量控制至关重要.
- 传统方法通常涉及危险的溶剂,并产生大量的废物.
- 开发可持续和高效的分析方法是制药行业的优先事项.
研究的目的:
- 开发和验证一种UV-Vis光谱法,用于同时量化普拉苏格勒 (PRA) 和阿司匹林 (ASP).
- 通过化学测量技术来增强该方法,特别是主要成分回归 (PCR) 和部分最小平方 (PLS) 回归.
- 评估该方法是否符合绿色和白色化学原则.
主要方法:
- 紫外线-Vis光谱光度与化学分析 (PCR和PLS) 相结合.
- 方法验证的准确性,精度和稳定性.
- 使用分析生态尺度和RGB12算法对环境影响的评估.
主要成果:
- 实现了高准确度和精度,平均回收率>100%和RSD<3%.
- PCR和PLS模型显示出出色的预测能力 (低RMSEP值).
- 该方法获得了高的绿色化学得分 (分析生态尺度:84,RGB12:94.4%),表明环境影响最小.
结论:
- 开发的UV-Vis光谱光度法与化学测量是准确的,精确的,强大的,适合于同时PRA和ASP量化.
- 该方法与绿色化学原则保持一致,为传统技术提供可持续和经济有效的替代方案.
- 这种方法对于常规的药物分析和质量控制有价值,优先考虑资源效率和环境责任.
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