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用流体结构相互作用方法评估跨导管假体心脏的血栓形成风险评估

Kyle Baylous¹, Brandon Kovarovic¹, Rodrigo R Paz²

¹Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA.

Computer methods and programs in biomedicine

|October 26, 2024

概括

这项研究引入了一种新的计算方法,用于评估透气管大动脉 (TAVR) 血栓的风险. 流体结构相互作用 (FSI) 方法改善了TAVR设备设计和患者特定风险评估.

科学领域:

生物医学工程生物医学工程
计算流体动力学的流体动力学.
心血管器械心血管器械

背景情况:

超导管大动脉置换 (TAVR) 越来越常见,但危及生命的血栓事件仍然令人担忧.
目前的体外血栓生成性测试具有挑战性,需要先进的计算方法.
修订后的ISO标准现在包括对心血管植入物风险评估的计算测试.

研究的目的:

开发和验证流体结构相互作用 (FSI) 方法,以评估跨导管大动脉 (TAVR) 的血栓发生风险.
用这种方法来优化工程和TAVR设备的临床评估.
从设计到临床应用,增强假体门的血栓阻力.

主要方法:

实现了一个使用ANSYS LS-DYNA用于计算流体动态的FSI框架.
通过将in silico结果与商业TAVR门的基准测试和文献数据进行比较,验证了数值模型.
通过使用ANSYS EnSight在虚拟血小板上计算压力积累 (SA) 来分析血栓形成风险.

主要成果:

在模拟准确地预测了TAVR的性能,流量与实验结果相匹配约93%.
瞬间的血小板应力达到10Pa左右,使用各种TAVR传单设计.
针对患者的具体建模揭示了"轻度"膜漏洞的显著血栓发生风险,中位数SA几乎是激活值的两倍.

结论:

开发的FSI方法允许改善假体门的血栓阻力.
它通过识别关键的说明书设计参数来减轻血栓形成风险,促进了设备的优化.
这种方法对于患者特定的TAVR设备评估和其他接触血液设备的风险评估是有价值的.

关键词:

心血管植入物是如何使用的流体结构相互作用的相互作用心脏门的心脏门在TAVRR中,我们可以看到.发生血栓的风险发生血栓的风险血栓是因为血栓.

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