在局部发达的头部和部状细胞癌中,PD-L1,PD-L2和炎症基因表达特征的表达
1Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul.
ESMO open
|October 26, 2024
概括
高T细胞炎症基因表达特征 (TcellinfGEP) 状态,而不是PD-L1或PD-L2表达,独立预测了晚期头癌的更长生存期. 这一发现影响了对PD-1/PD-L1疗法的评估.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 瘤免疫微环境对于癌症治疗反应和耐药性至关重要.
- 调查编程死亡配体1 (PD-L1),PD-L2和免疫基因表达对于理解头部和部状细胞癌 (HNSCC) 至关重要.
研究的目的:
- 描述PD-L1,PD-L2和T细胞炎症基因表达特征 (TcellinfGEP) 在局部区域高级HNSCC (LA HNSCC) 中.
- 评估这些生物标志物与临床结果的关联,包括总生存率和无复发生存率.
主要方法:
- 对366名在韩国 (2000-2015年) 接受治疗的LA HNSCC患者的回顾性分析.
- 对PD-L1,PD-L2表达和T细胞GEP的评估.
- 生物标志物之间的相关性分析及其与生存终点的关联.
主要成果:
- 高的PD-L1 (83.6%),PD-L2 (85.4%) 和TcellinfGEP (73.2%) 是常见的.
- PD-L1和PD-L2之间的中等相关性 (r=0.50);与T细胞infGEP (0.41-0.45) 的相关性较弱.
- 在多变量分析中,高T细胞infGEP是延长整体生存和无复发生存的唯一独立预测因子.
结论:
- 高T细胞GEP状态是LA HNSCC患者改善生存的重要独立预测因素.
- 在这个队列中,PD-L1和PD-L2表达与生存没有独立相关.
- 这些发现可能有助于选择患者接受针对HNSCC中PD-1/PD-L1通路的治疗.
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