易挥发性有机化合物暴露和代谢综合征的关联
Hee Byung Koh1, Jae Ho Chung1, Sung Jin Moon1
1Department of internal Medicine, International St. Mary`s Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea.
Environmental toxicology and pharmacology
|October 26, 2024
概括
挥发性有机化合物 (VOC) 与代谢综合征有关. 尿中较高的N-Acetyl-S-(phenyl) -L-cysteine (SPMA) 水平与代谢综合征风险及其组成部分如高血压有显著的相关性.
科学领域:
- 环境健康 环境健康
- 代谢疾病 代谢疾病
- 毒理学 毒理学 毒理学
背景情况:
- 挥发性有机化合物 (VOC) 导致累积毒性和各种疾病.
- 代谢综合征是一个日益严重的公共卫生问题,具有复杂的病因.
研究的目的:
- 调查尿液中VOC度与韩国人口中代谢综合征风险之间的关联.
- 识别与代谢综合征相关的特定VOC及其相关风险因素.
主要方法:
- 分析了1771名参加2023年韩国国家健康和营养检查调查的数据.
- 测量各种挥发性有机化合物的尿度,包括SPMA,2-MHA等.
- 使用后勤回归来评估关联的统计分析,并对潜在的混因素进行调整.
主要成果:
- 在患有代谢综合征的个体中,尿液中的BMA,2-MHA,PGA,SPMA,3-HPMA,BPMA和DHBMA度升高.
- N-Acetyl-S-(phenyl) -L-cysteine (SPMA) 与代谢综合征 (OR: 1.71) 有显著的积极关联.
- SPMA和2-MHA与升高的空腹血糖 (FBG) 损伤有关,SPMA与高血压有关.
结论:
- 这项研究表明,在韩国人口中,几种VOC与代谢综合征之间存在显著的关联.
- 特别是尿中的SPMA水平,与代谢综合征及其组成部分有着实质性的正相关性.
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