小左心室腔的大小和死亡率在一个大的人口一般
David Leibowitz1, Donna Zwas1, Offer Amir1
1Heart Institute, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
The American journal of cardiology
|October 26, 2024
概括
一个小的左心室 (LV) 腔大小,以前未在一般人群中进行研究,与增加的死亡风险有关. 这一发现适用于所有年龄组和性别,突出了一个新的心血管风险因素.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 公共卫生 公共卫生
背景情况:
- 左心室 (LV) 扩大意味着不良的心脏重塑和不良预后.
- 之前的研究表明,小 LV 腔大小的小患者子组存在心血管风险.
- 在一般人群中,小LV腔大小对预后的影响在很大程度上未被研究.
研究的目的:
- 为了研究小左心室 (LV) 腔大小与所有原因的死亡率之间的关联,在一个大型的,一般人口队列.
- 为了确定小的LV腔大小是否是不同的人口群体死亡率的独立预测因素.
主要方法:
- 在2011年至2023年间对46529名接受心声回声扫描的受试者进行了回顾性分析.
- 根据美国心声学会心声学指南定义的小型LV腔室尺寸 (男性的末端透气直径<42毫米,女性<37.8毫米).
- 多变量分析评估了小 LV 尺寸与全因死亡率之间的关联,并对临床和心声学变量进行调整.
主要成果:
- 在3,787名受试者中发现了小LV腔大小,与年龄较大和身体下部表面积有关.
- 较高的相对墙壁厚度和E/e'比率在具有小LV腔的受试者中观察到.
- 在多变量分析中,无论年龄或性别,小型LV腔室大小显著预测了所有原因的死亡率 (HR 1.34,95% CI 1.22-1.46,p <0.001).
结论:
- 小左心室 (LV) 腔的大小是广泛患者群体所有原因死亡率的重要,独立的预测指标.
- 小 LV 尺寸与死亡率之间的关联在年轻人和老年人,以及男性和女性中一致.
- 需要进一步的研究,以了解潜在的机制,并为患有小LV腔室的个人制定有针对性的预防策略.
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