慢性肝病在胆管癌中的患病率:一个元分析
Ethan Kai Jun Tham1, Ryan Yanzhe Lim1, Benjamin Koh1
1Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
概括
大约25%的胆管癌 (CCA) 患者有潜在的慢性肝病. 此外,大约10%的这些患者被诊断为肝硬化,突出显著的并发症.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 慢性肝病是胆管癌 (CCA) 的已知的危险因素.
- 在CCA患者中,并发性慢性肝病的确切患病率尚不清楚.
- 了解这种关联对于风险分层和患者管理至关重要.
研究的目的:
- 确定诊断为胆管癌 (CCA) 的个体中慢性肝病的患病率.
- 根据地理位置和瘤位置分层发现.
- 阐明不同慢性肝病和CCA亚型之间的关系.
主要方法:
- 进行了单臂元分析.
- 在MEDLINE和EMBASE数据库中搜索相关研究,截至2024年8月10日.
- 汇集了来自109项研究的数据,其中包括118,068名被诊断患有CCA的个人.
主要成果:
- 在CCA患者中,慢性肝病的综合患病率为25.23%.
- 肝硬化发生在10.21%的CCA患者中.
- 慢性肝病在肝内CCA中比肝外CCA更为普遍,除了原发性硬化性胆道炎.
结论:
- 几乎四分之一的胆管癌患者有潜在的慢性肝病.
- 十分之一的胆管癌患者患有肝硬化.
- 这些发现强调了CCA人群中慢性肝病的重大负担.
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