门诊密集营养治疗改善了与酒精有关的ACLF男性的生存和脆弱性 - 随机对照试验
Patal Giri1, Sunil Taneja2, Nancy Sahni3
1Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
概括
门诊密集营养治疗显著改善了与酒精有关的急性至慢性肝衰竭 (ACLF) 患者的生存率,并减少了患者的脆弱性. 这种营养干预也减少了疾病的严重程度和住院治疗.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床营养学 临床营养学
- 老年病的医生 老年病的医生
背景情况:
- 营养状况对于管理急性至慢性肝衰竭 (ACLF) 至关重要,可能降低发病率和死亡率.
- 与酒精有关的ACLF在患者管理和康复方面提出了独特的挑战.
- 虚弱性是ACLF患者显著的并发症,影响结果.
研究的目的:
- 评估营养学家支持的门诊密集营养治疗 (OINT) 对酒精相关ACLF患者的生存和脆弱性的影响.
- 评估OINT对该患者群体的预后得分和住院率的影响.
主要方法:
- 一项随机对照试验,涉及70名患有与酒精有关的ACLF和虚弱的患者.
- 患者被随机分配到标准医学治疗 (SMT) 加上OINT或单独SMT.
- 主要结局是3个月的生存期;次要结局包括脆弱性,预后得分和住院治疗.
主要成果:
- 门诊密集营养治疗 (OINT) 显著改善了3个月的存活率 (91.4%vs57.1%,P<.00).
- OINT导致肝脏脆弱指数 (LFI) 得分显著改善,并减少了疾病严重程度 (MELD,MELD-Na,AARC得分).
- 接受OINT治疗的患者住院次较少 (17%与45.7%,P = .01).
结论:
- 门诊密集营养治疗是与酒精有关的ACLF的高效干预措施.
- OINT显著提高了生存率,改善了脆弱性,并减少了疾病的严重程度和住院治疗.
- 这项研究强调了营养支持在管理ACLF中的关键作用.
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