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相关概念视频

Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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相关实验视频

Updated: May 3, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
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Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

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在面形态发生过程中骨质生成的单细胞转录组分辨率.

Erika Hudacova1, Pavel Abaffy2, Mehmet Mahsum Kaplan3

  • 1Department of Developmental Biology, Institute of Experimental Medicine, Czech Academy of Sciences, Videnska 1083, 14200 Prague, Czech Republic; Department of Cell Biology, Faculty of Science, Charles University, Vinicna 7, 12000 Prague, Czech Republic.

Bone
|October 26, 2024
PubMed
概括

面发育依赖于神经 (NCC) 细胞分化. 这项研究揭示了关键的分子驱动因素和Meis2 .

关键词:
骨头 骨头 骨头 骨头软骨 软骨是一种软骨.头骨面部的发展这是一个Meis2 .神经峰的神经峰

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Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis
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Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

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相关实验视频

Last Updated: May 3, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

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Published on: January 30, 2014

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Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis
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Published on: December 18, 2019

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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Published on: April 1, 2022

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科学领域:

  • 发展生物学 发展生物学
  • 遗传学 是一个遗传学.
  • 分子生物学分子生物学

背景情况:

  • 面形态发生涉及从神经细胞的复杂细胞命运决定.
  • 控制中细胞分化成面组织的分子机制在很大程度上是未知的.

研究的目的:

  • 阐明了背后的分子机制 面介质细胞分化.
  • 用单细胞转录学来识别面组织发育的关键分子决定因素.
  • 研究Meis2在面发育中的作用.

主要方法:

  • 来自小鼠胚胎的面介质细胞的单细胞RNA测序.
  • 光激活细胞分类 (FACS) 的Wnt1-Cre2后代.
  • 在体内验证已识别的分子标记物.
  • 野生类型和Meis2缺乏的小鼠模型的比较分析.

主要成果:

  • 在早期软骨和骨形成期间,在面介质中详细地绘制细胞异质性的地图.
  • 确定,牙,舌头,皮肤和周期性介质体发育的分子决定因素.
  • 梅斯2缺乏导致基因表达的改变,包括骨质和细胞粘附标记的增加.
  • 梅斯2缺乏导致中酶体细胞分化受损,骨化增加,骨,软骨和舌头形成缺陷.

结论:

  • 单细胞转录组学为面介质细胞分化提供了关键的见解.
  • 梅斯2在调节介质细胞分化和面骨和软组织发育方面发挥着至关重要的作用.
  • 了解这些分子通路对于解决面发育障碍至关重要.