在苏格兰共同开发环境导向的药物处方框架 - 一项混合方法研究
Lydia Niemi1, Naoko Arakawa2, Miriam Glendell3
1Environmental Research Institute, University of the Highlands and Islands, UK.
The Science of the total environment
|October 26, 2024
概括
水中的药品对公众健康构成风险. 这项研究制定了一个评估制药污染的框架,确定了克拉里素作为苏格兰淡水采集区的高风险污染物.
科学领域:
- 环境科学 环境科学
- 公共卫生 公共卫生
- 医疗保健服务研究 医疗服务研究
背景情况:
- 水生环境中的药品是一个全球性的问题.
- 苏格兰的医疗保健旨在减少药物使用对环境的影响.
- 医疗保健专业人员需要一个关于药品污染的知识支持工具.
研究的目的:
- 制定一个框架来评估药品对环境的影响.
- 为医疗保健专业人员创建一个知识支持工具.
- 专注于淡水流域的制药污染.
主要方法:
- 用于利益相关者就药品和模型因素达成共识的名义组技术.
- 贝叶斯信念网络建模用于预测环境影响 (危险和暴露).
- 整个苏格兰的制药污染风险在淡水流域的绘制地图.
主要成果:
- 模型计算了个别药品的污染风险得分.
- 克拉里思罗米显示出最高的风险,超过预测的无效度在大多数模拟的采集区 (>80%的概率在35/40).
- 与观察到的数据相比,模型通常预测过多的风险,表明需要精制因素和数据解析.
结论:
- 展示了一种新的跨学科方法,将环境信息纳入医疗保健决策.
- 开发的框架有助于理解和管理制药污染.
- 未来的工作将完善模型,并为医疗保健专业人员开发电子接口.
相关概念视频
Dimensions of Health and Illness
7.1K
The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
7.1K
Preclinical Development: Overview
4.3K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.3K
Drug Administration and Therapy Phases: Overview
412
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
412
Prescription, Nonprescription and Orphan Drugs
699
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
699
Drug Control Governance: Regulatory Bodies and Their Impact
144
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
144
Pharmacovigilance
778
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
778


