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在正常衰老中,大脑结构,氧化和 perfusion 功能的轨迹和性别差异

Di Wu¹, Yuanhao Li², Shun Zhang²

¹Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China.

|October 26, 2024

概括

大脑的结构和功能随着年龄的增长而发生变化,性别之间存在差异. 这项研究揭示了与年龄相关的大脑血流和氧气消耗的下降,为健康的衰老提供了洞察力.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
老年学是一门学科.

背景情况:

大脑结构,氧化和 perfusion 在衰老中至关重要.
神经血管单元 (NVU) 功能,以氧气消耗和 perfusion 合表示,随着年龄的增长而变化.
大脑功能中的与年龄相关的轨迹和性别差异尚未得到很好的定义.

研究的目的:

研究大脑结构,功能和年龄之间的关系.
为了检查在老化过程中大脑结构和功能中的性别差异.

主要方法:

137名健康成年人 (2069岁) 接受了MRI,包括3D-T1WI,3D-mGRE和3D-pCASL.
计算了氧气提取分数 (OEF) 和大脑血流 (CBF);获得了大脑氧气代谢率 (CMRO2).
一般化的添加模型分析了老化轨迹;相关性分析评估了OEF-CBF合.

主要成果:

女性比男性表现出更大的相对灰质 (rel_GM) 和更高的CMRO2和CBF.
CBF的灰质 (GM) 从20-32岁下降;CMRO2的GM从33-41岁下降;rel_GM在所有年龄段下降.
在皮质子区域中观察到CMRO2的广泛下降和CBF的分散下降;发现OEF和CBF之间存在显著的负相关性.

结论:

确定了大脑结构和功能的性别差异和年龄轨迹.
揭示了神经血管单元 (NVU) 在健康老龄化过程中的合的见解.
这些发现为研究与年龄相关的神经疾病提供了潜在的目标.

关键词:

衰老的衰老衰老的衰老大脑结构大脑结构大脑的血液流动.大脑的氧气代谢速度.神经血管合器的神经血管合器神经血管单位神经血管单位氧气提取分数的氧气提取分数

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