针对性无释放的L-氨酸诱导的hesperetin自组装纳米颗粒用于性结肠炎干预
Xuesong Chi1, Tao Chen1, Fengxian Luo1
1SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
新的天然纳米颗粒有效地清除反应性氧物种 (ROS) 并减少性结肠炎 (UC) 中的炎症. 这种口服治疗针对炎症的结肠区域,通过减少氧化应激和修复肠道屏障,为管理UC提供了一个有前途的治疗策略.
科学领域:
- 生物医学纳米技术 生物医学纳米技术
- 胃肠病学 胃肠病学
- 材料科学 材料科学 材料科学
背景情况:
- 反应性氧物种 (ROS) 的过度生产推动了性结肠炎 (UC) 的发病.
- 持续的ROS-炎症周期加速了UC的发展.
- 有针对性的ROS清理对于有效的UC管理至关重要.
研究的目的:
- 为了合成和评估自然的,无载体纳米粒子 (HST-ArgNP) 用于UC干预.
- 评估HST-ArgNP的ROS清除和抗炎性质.
- 在UC小鼠模型中研究HST-ArgNP的向输送和治疗疗效.
主要方法:
- 通过曼尼赫反应和π-π堆叠合成基于素 (HST),L-素 (L-Arg) 和素 (VA) 的纳米粒子 (HST-Arg NP).
- 评估抗氧化能力,胃肠道稳定性,以及在炎症结肠组织中有针对性的积累.
- 在硫酸 (DSS) 诱导的UC小鼠模型中,对ROS触发的氧化 (NO) 释放和治疗效果的评估.
主要成果:
- HST-Arg NPs表现出良好的抗氧化能力和稳定性,可用于口服.
- 负电荷的NP选择性地积聚在负电荷的炎症结肠区域.
- 在体内研究表明,结肠损伤显著减轻,减少了促炎性细胞因子,改善了肠道屏障完整性.
- 在炎症微环境中观察到ROS触发的NO释放.
结论:
- 没有天然载体的HST-ArgNP为UC干预提供了有针对性和有效的策略.
- 这些纳米粒子成功地清除ROS,并在炎症部位提供气体干预.
- 这种方法为开发用于炎症疾病的新型口服纳米粒子配方提供了有希望的基础.
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