妊娠期有机酸 (OPEs) 和青春期的执行功能:HOME研究
Ann M Vuong1, Zana Percy2, Weili Yang2
1Department of Epidemiology and Biostatistics, University of Nevada Las Vegas, School of Public Health, Las Vegas, NV, USA.
Environmental research
|October 26, 2024
概括
孕期暴露于有机酸 (OPEs),如 bis-2-chloroethyl phosphate (BCEP),可能会对青少年的执行功能产生负面影响. 建议对更大的队列进行进一步研究,以证实这些发现.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 有机酸 (OPE) 是一种已知的神经毒剂.
- 有限的流行病学数据存在于产前OPE暴露与儿童执行功能之间的联系.
研究的目的:
- 研究怀孕期间母亲尿液中OPE代谢物度与12岁青少年执行功能之间的关联.
- 确定可能影响神经发育结果的特定OPE.
主要方法:
- 利用了在HOME研究中的223个母亲-青少年双的数据.
- 在妊娠期间测量尿中OPE代谢物 (BCEP,DPHP,DNBP).
- 在12岁时使用执行功能的行为评分清单 (BRIEF2) 评估了青少年的执行功能.
- 采用多个信息模型和贝叶斯内核机器回归 (BKMR) 进行统计分析.
主要成果:
- 在26周孕期二乙酸盐 (BCEP) 的升高与自我报告的执行功能较差相关 (认知调节指数,情绪调节指数,全球执行复合).
- 在16周时较高的二酸 (DPHP) 与较低的家长报告的全球高管复合分数相关.
- 经过BKMR分析,BCEP和di-n-butyl酸盐 (DNBP) 在26周时被认为是特定执行功能领域的重要贡献者.
结论:
- 孕期暴露于OPE代谢物,特别是BCEP,可能会对青少年的执行功能产生不利影响.
- 研究结果表明,OPE可能对神经发育产生影响,需要进一步调查.
- 该研究建议进行更大规模的队列研究,以达到统计学意义并确认这些关联.
更多相关视频
07:08Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
6.0K
08:28Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
Published on: April 26, 2018
5.9K
相关概念视频
Anticholinesterase Agents: Poisoning and Treatment
796
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
796
Oogenesis
63.5K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.5K
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
