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Updated: Aug 3, 2026

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
10:40

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

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在糖尿病相关的认知障碍中,TREM1通过PERK途径诱导微质铁亡

Yujing Zhao1, Hongyan Guo1, Qiao Li2

  • 1Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.

Experimental neurology
|October 26, 2024
PubMed
概括

糖尿病相关的认知障碍包括微质铁亡. 在骨髓细胞1 (TREM1) 上表达的触发受体加剧了微质中的铁积累和氧化应激,导致认知能力下降. 抑制TREM1可能是一种治疗策略.

关键词:
认知障碍 认知障碍是一种认知障碍.铁性化 (ferroptosis) 是一种微质细胞中的微质细胞佩克 (Perk) 是一种可怕的东西.这就是T2DM.这就是TREM1的特点.

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