种族,民族和社会决定因素对免疫检查点治疗后的结果的影响

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Rahul K Nayak¹, Meili Aiello², Laneisha Marielis Maldonado¹

¹Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.

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|October 26, 2024

概括

免疫检查点封锁 (ICB) 试验往往不足以代表来自全球南方的非白人患者和人口. 未来的试验必须增加多样性,以确保公平的癌症治疗结果.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
临床试验分析

背景情况:

免疫检查点封锁 (ICB) 是癌症治疗的一个重大进步.
影响ICB疗效和副作用的因素需要进一步调查.

研究的目的:

审查种族,年龄,性别和社会决定因素对ICB结果的影响.
评估关键ICB试验中的参与者人口统计数据.

主要方法:

对ICB试验发表的文献进行系统审查.
对2期和3期试验的人口统计数据和结果的分析.

主要成果:

大多数试验报告了基本的人口统计数据,但缺乏关于社会决定因素或肥胖的数据.
试验通常以性别为代表,但代表性不足的非白人参与者和全球南方人口.
根据人口统计数据对不良事件的子组分析很少被报告.

结论:

对ICB疗法的临床试验需要更大的人口多样性.
增加多样性对于公平的癌症治疗结果至关重要.

关键词:

组合疗法是一种联合疗法.血液性恶性瘤血液性恶性瘤免疫检查点抑制剂免疫检查点抑制剂免疫相关不良事件 - irAEAE 固体瘤是一个固体瘤.

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