药物间药物相互作用与尼拉马特里尔维尔/里托纳维尔的药物监测
Victoria Hendrick1, Erast Pohorylo2, Lubna Merchant3
1Worldwide Medical and Safety, Pfizer Research and Development, Sandwich, Kent, UK.
Infectious diseases and therapy
|October 27, 2024
概括
尼马特里尔维尔/里托纳维尔 (NMV/r) 药物相互作用报告率较低,大多数病例不严重. 仔细使用交互资源可以确保安全的NMV/r治疗COVID-19.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 药品安全 药品安全
背景情况:
- 尼尔马特里尔维尔/里托纳维尔 (NMV/r) 是高风险的非住院COVID-19患者的关键治疗方法.
- 里托纳维尔的酶抑制需要仔细考虑药物相互作用 (DDI).
- 在NMV/r不良事件的Pfizer全球安全数据库上进行了现实数据分析.
研究的目的:
- 分析与NMV/r与相互作用药物使用相关的不良事件 (AE) 的现实数据.
- 评估潜在药物相互作用 (DDI) 的频率和性质与NMV/r.
主要方法:
- 从NMV/r授权到2023年10月31日的Pfizer全球安全数据库中提取了DDI病例.
- 总结了并发治疗,特定的副作用和临床结果.
- 估计的总体NMV/r暴露使用分发的药物数据来计算报告率.
主要成果:
- 在全球范围内,在19,617,670名暴露于NMV/r的患者中报告了966名潜在的DDI.
- 美国DDI报告率为0.004% (14,646,990名患者中有594例).
- 辛巴斯塔丁和塔克罗利斯是最常见的药物; 失血症是最常见的AE.
结论:
- 低的DDI报告率表明NMV/r可以安全管理.
- 利用药物相互作用资源对于在NMV/r治疗期间降低风险至关重要.
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