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补充维生素C可以改善胎盘功能,并改变吸烟者的胎盘基因表达
Lyndsey E Shorey-Kendrick1, Cindy T McEvoy2, Shannon M O'Sullivan1
1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Ave, Beaverton, OR, 97006, USA.
Scientific reports
|October 27, 2024
概括
怀孕期间母亲吸烟会损害婴儿的肺功能. 怀孕期间补充维生素C可以改善胎盘功能和吸烟者的血流,从而可能改善婴儿健康结果.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 营养科学 营养科学
背景情况:
- 怀孕期间母亲吸烟 (MSDP) 会降低后代的肺功能.
- 尼古丁暴露会影响胎盘功能和胎儿发育.
- 产前维生素C补充剂可以抵消MSDP的一些不良影响.
研究的目的:
- 研究是否维生素C补充剂减轻MSDP对人类吸烟者的胎盘结构,功能和基因表达的影响.
- 用多普勒超声波评估维生素C对胎盘血管功能的影响.
- 为了探索吸烟者的胎盘中的基因表达变化,补充了维生素C.
主要方法:
- 研究了一组来自VCSIP随机临床试验 (NCT01723696) 的孕妇吸烟者和孕妇非吸烟者的子组.
- 多普勒超声波评估脉多普勒速度 (Vmax).
- 通过RNA测序分析了胎盘基因表达.
主要成果:
- 与非吸烟者相比,接受安慰剂的吸烟者减少了脉Vmax.
- 吸烟者的维生素C补充剂显著改善了Vmax,使其正常化到非吸烟者的水平.
- RNA测序揭示了维生素C改变了对血管和心脏发育至关重要的基因的mRNA表达.
结论:
- 怀孕期间补充维生素C可以改善吸烟母亲的胎盘血管功能.
- 这些改进表明,尽管母亲吸烟,但维生素C的潜在机制可以提高后代的健康.
- 进一步的研究可以阐明产前维生素C对在子宫内暴露于吸烟的婴儿的长期益处.
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