亚皮干膜沉积物与心血管疾病的关联
Natan Lishinsky-Fischer1, Kinneret Misgav2, Itay Chowers1
1Ophthalmology Department, Hadassah Medical Center, Jerusalem, Israel.
Scientific reports
|October 27, 2024
概括
与年龄相关的黄斑变性 (AMD) 患者的视网膜下德鲁塞诺伊德沉积 (SDD) 与心血管疾病 (CVD) 有关. 这一发现表明视网膜和心血管疾病之间有共同的途径,有助于评估心血管疾病风险.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 医学研究 医学研究
背景情况:
- 在一些患有与年龄相关的黄斑退行症 (AMD) 的患者中观察到下视网膜状沉积物 (SDD).
- 建议SDD与心血管疾病 (CVD) 之间存在潜在的相关性.
- 作为心血管疾病的预测因素,SDD的临床意义需要进一步调查.
研究的目的:
- 调查AMD患者中SDD的存在与患有心血管疾病或接受心血管手术的可能性之间的联系.
- 确定SDD是否可以作为AMD人口中心血管风险的生物标志物.
主要方法:
- 追溯队列研究包括597名患有AMD的患者,根据SDD的存在 (n=332) 或缺席 (n=265) 分类.
- 用光谱域光学连贯性断层扫描 (SD-OCT) 来评估SDD,用蒙面评分员注释的扫描来评估SDD.
- 电子医疗记录 (EMR) 用ICD-9代码分析了患者人口统计,心血管诊断和CVD相关程序.
主要成果:
- 与没有SDD的患者相比,患有SDD的AMD患者的CVD诊断或接受心血管手术的可能性显著更高.
- 通过皮肤进行的透光冠状动脉血管造形术 (PTCA) 发现了显著的关联,赔率比为2.73 (95% CI [1.21,6.13],p=0.02).
- 多变量分析证实了SDD与PTCA史之间的独立关联,即使考虑到其他共变量.
结论:
- 在AMD患者中SDD的存在与特定的严重心血管疾病,特别是PTCA相关.
- 这些发现表明,SDD和CVD可能具有共同的潜在致病机制.
- SDD可能成为AMD患者心血管风险增加的临床指标.
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