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来自Candida tropicalis的维生素B3通过促进依赖IL-17A/IL-22的上皮屏障功能来对肠道炎症产生保护作用

Ha T Doan¹, Li-Chieh Cheng¹, Yi-Ling Chiu¹

¹Department of Life Science, National Taiwan University, Taipei, Taiwan.

|October 27, 2024

概括

肠道真菌Candida tropicalis通过促进屏障功能和细胞修复,有助于维持肠道健康. 它通过改变维生素B3的新陈代谢来实现这一目标,将尼古丁胺转化为保护性尼古丁酸.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

像Candida tropicalis这样的食用真菌在肠道中很常见,但它们在肠道平衡中的作用尚不清楚.
了解C. tropicalis如何影响肠道屏障功能和炎症对于其在健康和疾病中的作用至关重要.

研究的目的:

调查开始性Candida tropicalis影响肠道平衡和屏障功能的机制.
探索C. tropicalis殖民对肠道炎症和上皮细胞增殖的影响.

主要方法:

用化学诱导的大肠炎和细菌感染的小鼠模型来评估C. tropicalis的影响.
使用了肠道殖民,基因表达分析 (IL-17A,IL-22),代谢学和体内功能测试.
进行了基准菌株和C. tropicalis临床菌株的比较.

主要成果:

热带菌的参考菌株改善了肠道炎症,并提高了IL-17A和IL-22的调节,增强了屏障功能和上皮细胞的增殖.
C. tropicalis改变了便维生素B3的新陈代谢,促进了尼古丁胺的转化为尼古丁酸,从而缓解了结肠炎症状.
来自候选症患者的C. tropicalis临床菌株没有显示对大肠炎的保护作用.

结论:

热带虫在通过调节维生素B3代谢来解决肠道炎症方面发挥着保护作用.
尼古丁酸是由C. tropicalis促进的,增强了表皮屏障功能和Th17细胞分化,提供治疗潜力.
在C. tropicalis对肠道炎症的保护功能方面存在菌株特异性差异.

关键词:

热带虫 (Candida tropicalis) 是一个热带虫它们的IL-17A是IL-17A.在IL-22中,我们可以看到IL-22.表面上皮质屏障的功能皮质细胞的增殖和扩散.炎症性肠病是一种炎症性肠病.粘膜免疫力粘膜免疫力维生素B3 维生素B3 是一种维生素.

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