乳酸菌种对产生酸盐的肠道微生物群产生差异性影响,以驱动中枢神经系统自身免疫力
Theresa L Montgomery1, Lucinda C Toppen2, Korin Eckstrom3
1Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT, USA.
Gut microbes
|October 27, 2024
概括
乳杆菌reuteri通过耗尽产生短链脂肪酸 (SCFA) 的有益肠道细菌来加剧多发性硬化症 (MS). 食纤维可以抵消这种效应,这表明MS治疗的综合方法.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 来自肠道微生物群的短链脂肪酸 (SCFA) 有抗炎作用.
- 在多发性硬化症 (MS) 中,SCFA水平和生产者减少.
- 在MS中SCFA枯竭的机制是未知的.
研究的目的:
- 使用EAE模型调查MS中SCFA枯竭的机制.
- 确定特定的共生细菌 (L. reuteri,L. murinus) 对中枢神经系统自身免疫的影响.
- 探索饮食在调节肠道微生物群和SCFA生产中的作用.
主要方法:
- 在EAE模型中与L. reuteri和L. murinus进行殖民.
- 在体内和体外微生物组和代谢组的分析.
- 饮食纤维调节和对L. reuteri.的基因组分析.
主要成果:
- 在L. reuteri的殖民化中,EAE恶化,SCFA生产细菌枯竭.
- 在体外,L. reuteri直接抑制了SCFA生产者和丁酸盐生产.
- 食纤维补充剂使SCFA水平正常化,并废除了L. reuteri.引起的EAE恶化.
结论:
- 肠道微生物群的相互作用可以以饮食依赖的方式影响中枢神经系统自身免疫.
- 其他肠道细菌对SCFA生产者的消耗可能有助于MS的发病.
- 多发性硬化症的治疗策略可能需要饮食干预和微生物组调节.
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