在美国成年人中,炎症指标 (MLR,NLR,SII,SIRI和AISI) 与勃起功能障碍之间的关联:NHANES 2001-2004
Heng Liu1, Huqiang Dong2, Mixue Guo3
1Department of Urology, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, PR China.
Journal of health, population, and nutrition
|October 27, 2024
概括
炎症指标如单细胞与淋巴细胞比率 (MLR) 与勃起功能障碍 (ED) 有关. 升高的MLR可以预测ED风险,特别是在50岁以上的男性中.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 安德罗学与人类学
- 心血管健康 心血管健康
- 炎症研究 炎症研究
背景情况:
- 勃起功能障碍 (ED) 是一种常见的疾病,有多因素的原因.
- 炎症越来越多地被认为是导致ED的因素.
- 之前的研究还没有全面评估与ED相关的多个炎症标志物的同时.
研究的目的:
- 调查各种炎症标志物与ED的患病率之间的关联.
- 为了确定可能预测ED风险的特定炎症生物标志物.
- 探索这些标志物的诊断实用性,以识别ED的个体.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2001-2004) 的横截面分析.
- 通过自我报告和丸激素水平评估ED.
- 分析炎症标志物,包括中性细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR),全身免疫炎症指数 (SII),全身炎症反应指数 (SIRI) 和总体炎症指数 (AISI).
- 统计方法包括多变量逻辑回归,子组分析,通用增量建模 (GAM) 和接收器操作特征 (ROC) 曲线分析.
主要成果:
- 总共分析了3610名参与者,ED患病率为18.91%.
- 五个炎症指标 (Ln-NLR,Ln-MLR,Ln-SII,Ln-SIRI,Ln-AISI) 显示出与ED有显著的积极关联.
- 滑曲线适配显示了这些炎症标志物和ED之间的非线性正相关性.
- 亚组分析表明,50岁以上男性的相关性更强.
- 与其他标志物相比,ROC分析表明,MLR在预测ED方面具有最高的诊断性能 (AUC = 0.616).
结论:
- 高水平的MLR与ED的风险增加有关.
- 对于预测ED,MLR可能比NLR,SIRI,AISI和SII更有效的生物标志物.
- 患有较高MLR水平的男性应被告知他们患ED的风险增加.
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