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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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9岁的越南儿童的血清二二水平下降,原因是二氧化碳暴露区域.

Oanh Thi Phuong Nguyen1, Seijiro Honma2, Phuc Duc Hoang3

  • 1School of Preventive Medicine and Public Health, Hanoi Medical University.

Environmental health and preventive medicine
|October 27, 2024
PubMed
概括

越南热点地区通过母乳暴露于二氧化物可能会影响儿童的内分泌系统. 这项研究发现,暴露在二氧化的儿童中,二氧化 (DHT) 水平降低,激素比率改变.

关键词:
9岁的孩子们的孩子.素干扰的破坏测试激素二氨酸 (Dihydrotestosterone) 是一种暴露于二氧化的情况.测试激素 测试激素是什么越南队列的队列是越南人.

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科学领域:

  • 环境科学 环境科学
  • 内分泌学 在内分泌学.
  • 儿科 儿科 儿科

背景情况:

  • 二氧化物是持久性环境污染物和内分泌干扰物.
  • 生活在越南二氧化碳热点地区的儿童面临暴露的风险.
  • 需要进行长度研究,以了解二氧化碳对儿童发育的影响.

研究的目的:

  • 调查越南儿童暴露于二氧化碳和内分泌疾病之间的关系.
  • 评估母亲通过母乳接触二氧化对儿童荷尔蒙平衡的影响.
  • 分析二氧化暴露和未暴露区域的儿童的类固醇激素水平和酶活性.

主要方法:

  • 在母乳中测量了17种二氧化/类原体,在9岁儿童中测量了7种血清类固醇激素.
  • 来自越南二氧化碳热点和非暴露区域的儿童之间的水平比较.
  • 基于激素水平比率计算的类固醇代谢酶比率.

主要成果:

  • 热点地区的二氧化物水平明显高于热点地区.
  • 热点地区的儿童身高和体重较低,与二氧化水平相反相关.
  • 暴露儿童的二二 (DHT) 水平和DHT/的比率显著较低,这表明DHT生物合成受损.

结论:

  • 通过母乳暴露于的二氧化碳可以影响孩子的内分泌系统,直到9岁.
  • DHT生物合成特别受到二氧化暴露的影响.
  • 调查结果强调了二氧化污染对儿童的长期健康风险.