林奇综合征查和监测趋势在日本的胃肠科医生:一个调查问卷基于调查的分析
Yuji Urabe1, Shiro Oka1, Hideki Ishikawa2
1Department of Gastroenterology, Hiroshima University Hospital, Japan.
Internal medicine (Tokyo, Japan)
|October 27, 2024
概括
在日本,林奇综合征 (LS) 查得到了改善,人们对普遍瘤查 (UTS) 的认识和采用增加了. 这导致更多的LS患者被诊断和监测,尽管存在潜在的偏见.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 林奇综合征 (LS) 是一种遗传性疾病,增加癌症风险.
- 有效的查和监测对于管理LS至关重要.
- 了解日本的LS知识和实践的趋势很重要.
研究的目的:
- 评估林奇综合征的变化,日本的知识和实践趋势.
- 评估查方法对LS诊断和监测的影响.
- 为了识别LS的普遍瘤查 (UTS) 采用的时间变化.
主要方法:
- 在2020年和2022年对3574名日本胃肠病学会委员进行了两次横截面问卷调查.
- 分析回应,以比较两个调查期间之间的知识和实践趋势.
- 评估与LS相关的知识,查实践和患者管理的时间变化.
主要成果:
- 显著提高认识和采用普遍瘤查 (UTS) 进行初级LS查.
- 在LS患者的化疗选择中,BRAF V600E测试的使用率更高.
- 新诊断的LS患者数量增加,以及每位医生监视的患者数量增加.
- 加强LS查的医生报告说,新确诊病例的增加更大.
结论:
- 扩大查实践,包括UTS,可能导致日本诊断和监测LS患者的增加.
- 采用UTS的增加可能会带来偏见,可能会高估查变化的影响.
- 在日本,持续监测和完善LS查策略是有必要的.
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