异常性炎的特征及其与低级系统性炎症的关联
Dan Ping Ruan1, Ye Kan Li1, Xiao Xian Qian2,3
1Department of Stomatology, Minhang Hospital, Fudan University, Shanghai, China.
Oral diseases
|October 28, 2024
概括
异常口臭是一种罕见的疾病,与低级系统性炎症 (LGSI) 有关. 分数呼出的氧化 (FeNO200) 显示出这种情况的高诊断能力.
科学领域:
- 医学研究 医学研究
- 呼吸系统医学 呼吸系统医学
- 炎症研究 炎症研究
背景情况:
- 异常口臭是一种罕见的临床发现,研究有限.
- 了解其根本原因,特别是全身炎症,至关重要.
研究的目的:
- 为了研究异常口臭症的特征.
- 探索其与低级系统性炎症 (LGSI) 的潜在关联.
主要方法:
- 追溯分析54名异常口臭患者与63名健康对照组.
- 对有机体评分 (OLS),呼出的挥发性硫化合物 (VSCs),炎症性细胞因子和部分呼出的氧化 (FeNO200) 的评估.
主要成果:
- 与对照组相比,异常口臭患者的FeNO200 (79.63%) 升高 (p <0.001).
- FeNO200水平与OLS (r=0.871) 和二甲基硫化物 (DMS) (r=0.485) 有正相关.
- 在一小部分患者 (5.56%) 观察到炎症性细胞因子的轻微升高.
结论:
- 异常口臭很少见,与LGSI相关,并可能与口外因素有关.
- FeNO200显示高灵敏度 (79.63%) 和特异性 (100%) 诊断异常口臭.
- 由于其诊断能力,FeNO200被推用于诊断异常口臭.
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