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在晚期甲状腺癌中,佩美特雷克塞德-碳白救援疗法

Kenzie K Lee¹, John C Morris^1,2, Aditi Kumar³

¹Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.

|October 28, 2024

概括

使用pemetrexed-carboplatin (PC) 的救生化疗在晚期甲状腺癌中显示出持久的反应. 这种治疗为耐火性疾病患者提供了有效的选择,包括厌塑性甲状腺癌 (ATC).

科学领域:

在瘤学瘤学.
甲状腺癌研究研究
化疗化疗是一种化学疗法.

背景情况:

晚期甲状腺癌常常在针对性的治疗中进展,需要有效的救援治疗.
对于耐火性晚期甲状腺癌患者,存在有限的生存选择.
在晚期甲状腺癌中,急需新的治疗策略.

研究的目的:

评估pemetrexed-carboplatin (PC) 作为高级甲状腺癌的救援治疗的疗效.
评估PC治疗的耐火性甲状腺癌患者的应答率和无进展生存率.
为了加强现有的临床试验数据,以证实pemetrexed在晚期甲状腺恶性瘤中的有效性.

主要方法:

患者的回顾性分析耐火性晚期甲状腺癌患者接受美雷克塞德 - 碳白 (PC) 治疗.
自2019年以来在梅奥诊所进行的研究.
包括患有形甲状腺癌 (ATC) 和差异化/差异化甲状腺癌 (DTC) 的患者.

主要成果:

七名患有分化或差分化甲状腺癌 (DTC) 的患者经历了持久的反应,中位数无进展生存时间为29个月.
一名患有形甲状腺癌 (ATC) 的患者,对多种先前疗法耐药,在第四线PC治疗中取得了持久的反应.
这位患有ATC的患者在初始反应后的12个多月内继续接受治疗.

结论:

佩美特雷克塞德 - 碳白 (PC) 证明了其作为治疗晚期甲状腺癌的救援疗法的强大有效性.
这些发现支持先前的I期临床试验数据,关于pemetrexed的有效性.
这种救援方案为患有最先进和耐火性甲状腺癌的患者提供了有前途的治疗选择.

关键词:

晚期甲状腺癌是什么?形性厌塑性厌塑性厌塑性差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异化差异放射性耐火材料放射性耐火材料在救援救援救援救援.

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