一个机器学习优化系统,用于脉动,光和化疗治疗,使用近红外响应的MoS2基微粒在乳腺癌模型中
Maria Kanelli1, Neelkanth M Bardhan1, Morteza Sarmadi1
1The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, United States.
ACS nano
|October 28, 2024
概括
一种新型的光激活微粒系统提供抗癌药物,并使用近红外激光照射进行局部热除. 这种多模式的癌症治疗显著增加了小鼠的生存率和根除了小鼠的瘤.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 由于传统治疗的高死亡率和副作用,进展性癌症需要多式疗法.
- 对于治疗持久性癌症来说,不那么侵入性,反复的治疗方式在临床上具有意义.
研究的目的:
- 开发一种可光激活的微粒系统,用于局部,脉动的药物输送和同时进行热除.
- 研究光热疗法和化疗在癌症治疗中的协同效应.
主要方法:
- 制造了装有二硫化物 (MoS2) 纳米片和抗癌药物 (多克索鲁比或紫) 的聚甲微粒 (200微米).
- 近红外激光照射触发光热加热 (≥50°C) 以释放药物和软化聚合物.
- 一个机器学习算法优化了激光操作条件,以控制开关热循环.
主要成果:
- 在低功率激光器的要求下,MoS2纳米板表现出高光热转换效率.
- 在4T1三阴性乳腺癌小鼠模型中的内注射导致3个激光治疗周期后具有协同光疗和化疗效应.
- 治疗导致平均存活时间为39天,并在主要部位完全根除瘤.
结论:
- 开发的微粒子系统提供按需,脉动的协同治疗,具有精确的定位和低侵入性.
- 这种方法在小瘤的重复治疗中具有治疗意义,并且没有与其他疗法产生交叉耐药性.
相关概念视频
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02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...