内源性激素水平对肥胖男性基础代谢率的影响
Jolijn Van Cauwenberghe1,2, Kristof Van Dessel1, Christophe De Block1,2
1Department of Endocrinology, Diabetology & Metabolism, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
Clinical endocrinology
|October 28, 2024
概括
在患有肥胖症的男性中,脱水氨硫酸 (DHEAS) 与基础代谢率 (BMR) 有积极的关联. 其他激素如,TSH,FT4和IGF-1在这个研究组中没有与BMR相关.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 基本代谢率 (BMR) 对于体重管理至关重要.
- 荷尔蒙对BMR的影响尚未完全理解,特别是在肥胖症中.
- 以前的研究往往缺乏身体组成的纠正,或专注于外源性激素.
研究的目的:
- 研究肥胖男性内源性激素水平和BMR之间的关联.
- 为了确定像,DHEAS,IGF-1,TSH和ft4这样的激素是否与BMR相关,独立于身体组成和年龄.
主要方法:
- 一项横截面研究包括457名男性,主要是肥胖 (BMI ≥30 kg/m2),被转诊进行代谢工作.
- 测量包括BMR,身体组成 (无脂肪质量,脂肪质量) 和,SHBG,DHEAS,IGF-1,TSH和FT4的血清水平.
- 线性回归模型被用来评估关联,控制无脂肪质量,脂肪质量和年龄.
主要成果:
- 脱氨硫酸 (DHEAS) 显示,在肥胖男性中,与 BMR 有显著的积极关联 (调整后的 R2 = 0.72).
- 丸激素 (总和自由),甲状腺刺激激素 (TSH),自由甲状腺素 (fT4) 和胰岛素样生长因子1 (IGF-1) 并没有与BMR相关.
- 指示DHEAS的回归方程有助于预测BMR与FFM,FM和年龄一起.
结论:
- 内源性DHEAS与肥胖男性的BMR积极相关.
- 在这个特定的人群中,,TSH,FT4和IGF-1似乎不会影响BMR.
- 结果仅限于肥胖和内源性激素水平的男性;不建议推断到其他群体.
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