探索光生物调节在肠道疾病的管理:一个简洁的批判性审查
Vanessa De Souza1, Marlon da Palma Cruz2, Dominique Cavalcanti Mello2
1Program in Medicine - Biophotonics, University Nove de Julho (UNINOVE), Rua Vergueiro, 239/245, São Paulo, SP, 01504-000, Brazil. vanessacuidador@gmail.com.
Lasers in medical science
|October 28, 2024
概括
在临床前研究中,光生物调制 (PBM) 显示出治疗炎症性肠病 (IBD),减少肠道炎症和改善粘膜完整性的前景. 需要进一步的临床研究来确定PBM作为IBD患者的安全有效治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠道疾病 (IBD),包括性结肠炎和克罗恩病,存在复杂的治疗挑战.
- 目前用于IBD的疗法可能具有有限的疗效和不良副作用.
- 光生物调制 (PBM) 或低水平光疗是治疗肠道疾病的新兴替代方案.
研究的目的:
- 审查目前关于PBM在治疗炎症性肠道疾病中的疗效的文献.
- 评估PBM作为IBD治疗或辅助策略的潜力.
- 发现研究缺陷,指导未来的临床研究.
主要方法:
- 在MEDLINE (PubMed) 和SCOPUS数据库中进行了系统的文献搜索.
- 包括1990年至2024年间发表的研究.
- 总共有72项研究被选中,其中9项专门关注IBD (性结肠炎,克罗恩病).
主要成果:
- 在小鼠的实验IBD模型中,PBM显示出显著的积极效应.
- 观察到的好处包括减少肠道炎症,改善粘膜完整性和免疫反应调节.
- 没有发现任何临床研究,这凸显了人类试验数据的差距.
结论:
- 作为治疗IBD的非侵入性补充疗法,PBM显示出相当大的潜力.
- 临床前发现表明PBM可以缓解肠道炎症的关键方面.
- 迫切需要将PBM研究从临床前模型推进到IBD治疗人类临床试验.
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