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设计具有仿生区域特征的关节软骨的策略:一个审查

Angela Semitela1, Paula A A P Marques1, António Completo1

  • 1Centre of Mechanical Technology and Automation (TEMA), Department of Mechanical Engineering, University of Aveiro, 3810-193 Aveiro, Portugal. angela.semitela@ua.pt.

Biomaterials science
|October 28, 2024
PubMed
概括

工程软骨需要区域分层来进行有效的再生和功能. 本综述探讨了创建生物模拟性关节软骨 (AC) 的策略,其中包括带地元素,以改善修复结果.

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Growth of Cartilage and Bone Tissue01:27

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...