女性生殖系统和甲状腺功能障碍:德黑兰甲状腺研究12年随访结果
Siavash Shariatzadeh1,2, Hossein Hatami3, Hengameh Abdi1
1Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Thyroid : official journal of the American Thyroid Association
|October 28, 2024
概括
女性生殖因素,如平价和堕胎,与甲状腺功能障碍有关. 多次分娩和堕胎与甲状腺问题相关,而堕胎史可能会降低明显的甲状腺功能低下风险.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 流行病学 流行病学
背景情况:
- 甲状腺功能障碍 (TD) 影响女性生殖能力,但反向关联不太清楚.
- 之前的研究显示了关于生殖状态和甲状腺功能的相互矛盾的结果.
- 这项研究调查了性别平等,堕胎史和更年期与TD患病率和发病率之间的联系.
研究的目的:
- 为了检查女性生殖状态 (平价,堕胎,更年期) 和甲状腺功能障碍之间的关联.
- 确定生殖史是否影响甲状腺疾病的发生和发展.
- 提供关于生殖系统和甲状腺健康之间的相互作用的见解.
主要方法:
- 对来自德黑兰甲状腺研究的2711名参与者的横截面分析.
- 在3年后随访间隔,对2191名甲状腺功能良好的参与者进行了生存分析.
- 使用了多项逻辑回归和多变量考克斯比例危险模型,并对混因素进行了调整.
主要成果:
- 多重平价 (≥4) 与在基线时明显甲状腺功能低下和亚临床甲状腺功能过高的几率增加有关.
- 多次堕胎与明显甲状腺功能障碍的更高几率有关.
- 多重平价与发生的甲状腺功能低下相关,而堕胎史显示发生的明显甲状腺功能低下的风险降低. 更年期状态没有显著的关联.
结论:
- 女性生殖因素,特别是性别平等和堕胎史,与甲状腺功能障碍的患病率和发病率有关.
- 这些发现强调了生殖事件与甲状腺健康之间的重要联系.
- 对这些关联背后的分子机制进行进一步研究是有必要的.
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