不对称的二甲基氨基与糖尿病病患者的足细胞病标记物的相关性
Pringgodigdo Nugroho1, Riahdo Juliarman Saragih2, Aida Lydia1
1Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
International journal of nephrology and renovascular disease
|October 28, 2024
概括
不对称的二甲基氨基 (ADMA) 与尿和糖尿病病 (DKD) 患者的podocin:nephrin比率呈现微弱的正相关性. 没有发现ADMA和尿液中多素水平之间有显著的联系.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- 糖尿病病 (DKD) 是末期病的主要原因.
- 尿中受尿细胞蛋白质 (如尼夫林和皮多) 标记的细胞病是DKD早期症状之一.
- 不对称二甲基氨基 (ADMA),一个内皮功能障碍生物标志物,与功能下降有关,但其在DKD进展中的作用尚不清楚.
研究的目的:
- 在DKD患者中研究ADMA水平与尿道内,皮多和皮多:内比率 (PNR) 之间的相关性.
主要方法:
- 一项涉及41名DKD门诊患者的横截面研究.
- 血清ADMA通过液体染色学测量;尿内和皮多辛通过ELISA测量.
- 进行相关性和回归分析以评估关系和混因素.
主要成果:
- ADMA显示出与尿内素 (r=0.353,p=0.024) 和PNR (r=-0.360,p=0.021) 的显著弱正相关性.
- 没有观察到ADMA和尿路波多辛之间有显著的相关性 (r=0.133,p=0.409).
- 身体质量指数被确定为多变量分析中的混因素.
结论:
- 在DKD患者中,ADMA与尿和PNR呈现弱正相关性.
- 在这个队列中,ADMA水平与尿道皮多辛没有显著的相关性.
- 这些发现有助于了解DKD进展中的内皮功能障碍机制.
关键词:
ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was that was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was that was was was was was was was was was was was was was was was was was was was was was was was was was was was was was糖尿病病 糖尿病病尼弗林是尼弗林中的一种.皮多辛是一种可怕的药物素:尼弗林的比率是什么?
