快速眼动睡眠行为障碍在多系统缩中的患病率和影响:系统性审查和元分析
Hui Wang1, Ting Zhang1, Wenhui Fan1
1Department of Neurology, Sichuan Taikang Hospital, Chengdu, China.
Frontiers in neurology
|October 28, 2024
概括
多重系统缩 (MSA) 经常与快速眼动睡眠行为障碍 (RBD) 相关,影响79.9%的患者. 那些患有RBD的人更年轻,更早发病,MSA症状更严重.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 神经退行性疾病 神经退行性疾病
背景情况:
- 多重系统缩 (MSA) 是一种神经退行性疾病,通常与快速眼动睡眠行为障碍 (RBD) 一起发生.
- 之前关于RBD患病率及其对MSA患者的影响的研究已经显示出不一致的结果.
- 关于RBD对MSA进展的影响存在重大知识差距,只有一项先前对MSA中RBD患病率的元分析.
研究的目的:
- 系统地审查和元分析RBD在MSA患者的患病率.
- 调查RBD对MSA的临床影响,包括发病年龄,疾病严重程度和人口统计因素.
- 为MSA和RBD之间的关联提供全面的概述.
主要方法:
- 一个系统的审查和对MSA和RBD研究的元分析.
- 在PubMed,Web of Science,Embase和Cochrane数据库中进行了搜索.
- 计算了患病率,几率比率 (OR) 和加权平均差异 (WMD) 的95%置信区间 (CI). 使用I平方统计学来评估异质性.
主要成果:
- 在598名受试者中,在MSA中聚睡眠学确认的RBD的综合患病率为79.9% (95% CI,68.8-89.3%).
- 患有RBD的MSA患者在检查时更年轻 (WMD -3.26岁),并且发病年龄更早 (WMD -3.27岁).
- 在男性MSA患者中,RBD更为普遍 (OR 2.11) 并与更高的UMSARS分数 (UMSARS I和IV) 相关.
结论:
- 在MSA中,多睡眠学确认的RBD的患病率高达79.9%.
- 患有RBD的MSA患者往往更年轻,疾病发病较早,症状更严重.
- 流行率的区域差异 (亚洲较低) 可能表明低估,需要进一步调查.
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